abstract：:The genes coding for the main molecules involved in the human immune system--immunoglobulins, human leucocyte antigen (HLA) molecules and killer-cell immunoglobulin-like receptors (KIR)--exhibit a very high level of polymorphism that reveals remarkable frequency variation in human populations. 'Genetic marker' (GM) al...

journal_title：Immunology

authors： Sanchez-Mazas A,Fernandez-Viña M,Middleton D,Hollenbach JA,Buhler S,Di D,Rajalingam R,Dugoujon JM,Mack SJ,Thorsby E

更新日期：2011-06-01 00:00:00

abstract：:The innate immune response provides the initial defence mechanism against infection by other organisms. However, an excessive immune response will cause damage to host tissues. In an attempt to identify microRNAs (miRNAs) that regulate the innate immune response in inflammation and homeostasis, we examined the differe...

journal_title：Immunology

authors： Niu Y,Mo D,Qin L,Wang C,Li A,Zhao X,Wang X,Xiao S,Wang Q,Xie Y,He Z,Cong P,Chen Y

更新日期：2011-05-01 00:00:00

abstract：:Despite extensive investigation of the signals required for development of T helper type 1 (Th1) and type 2 (Th2) immune responses, the mechanisms involved are still not well-defined. A critical role for Epstein-Barr virus-induced gene 3 (EBI3) in these responses has been proposed. EBI3, initially discovered as a tran...

journal_title：Immunology

authors： Dokmeci E,Xu L,Robinson E,Golubets K,Bottomly K,Herrick CA

更新日期：2011-04-01 00:00:00

abstract：:Francisella tularensis is a Gram-negative intracellular bacterium that is the causative agent of tularaemia. Concerns regarding its use as a bioterrorism agent have led to a renewed interest in the biology of infection, host response and pathogenesis. A robust T-cell response is critical to confer protection against F...

journal_title：Immunology

authors： Valentino MD,Maben ZJ,Hensley LL,Woolard MD,Kawula TH,Frelinger JA,Frelinger JG

更新日期：2011-03-01 00:00:00

abstract：:In mice, the plasma cell (PC) niche in the bone marrow is close to the haematopoietic stem cell (HSC) niche. We investigated whether PCs can be mobilized into the peripheral blood (PB) in healthy donors receiving granulocyte colony-stimulating factor (G-CSF) for the induction of HSC mobilization into the PB. G-CSF inc...

journal_title：Immunology

authors： Caraux A,Perez-Andres M,Larroque M,Requirand G,Lu ZY,Kanouni T,Rossi JF,Orfao A,Klein B

更新日期：2011-02-01 00:00:00

abstract：:Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interp...

journal_title：Immunology

authors： Wong WF,Kohu K,Chiba T,Sato T,Satake M

更新日期：2011-02-01 00:00:00

abstract：:6-Sulpho LacNAc dendritic cells (slanDC) are a major population of human blood DC that are highly pro-inflammatory, as characterized by their outstanding capacity to produce tumour necrosis factor-α and interleukin-12 (IL-12) and to prime antigen-specific T-cell responses. SlanDC were found to be present in inflamed t...

journal_title：Immunology

authors： Gschwandtner M,Schäkel K,Werfel T,Gutzmer R

更新日期：2011-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease that involves dysregulation of B and T cells. A tolerogenic peptide, designated hCDR1, ameliorates disease manifestations in SLE-afflicted mice. In the present study, the effect of treatment with hCDR1 on the CD74/macrophage migration inhibitory factor (MIF) ...

journal_title：Immunology

authors： Lapter S,Ben-David H,Sharabi A,Zinger H,Telerman A,Gordin M,Leng L,Bucala R,Shachar I,Mozes E

更新日期：2011-01-01 00:00:00

abstract：:Memory CD8(+) T cells regain function during a recall response, but the requirement of signals in addition to antigen during a secondary immune response is unknown. In this study, the ability of interleukin-7 (IL-7) to enhance memory CD8(+ ) CD45RA(- ) CD127(+) T-cell responses in health and in human immunodeficiency ...

journal_title：Immunology

authors： O'Connor AM,Crawley AM,Angel JB

更新日期：2010-12-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules present antigenic peptides derived from engulfed exogenous proteins to CD4(+) T cells. Exogenous antigens are processed in mature endosomes and lysosomes where acidic proteases reside and peptide-binding to class II alleles is favoured. Hence, maintenance of th...

journal_title：Immunology

authors： Crotzer VL,Glosson N,Zhou D,Nishino I,Blum JS

更新日期：2010-11-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection ...

journal_title：Immunology

authors： Mayuzumi H,Inagaki-Ohara K,Uyttenhove C,Okamoto Y,Matsuzaki G

更新日期：2010-11-01 00:00:00

abstract：:Although interleukin-21 (IL-21) potently activates and controls the differentiation of immune cells after stimulation in vitro, the role for this pleiotropic cytokine during in vivo infection remains poorly defined. Herein, the requirement for IL-21 in innate and adaptive host defence after Listeria monocytogenes infe...

journal_title：Immunology

authors： Ertelt JM,Johanns TM,Rowe JH,Way SS

更新日期：2010-10-01 00:00:00

abstract：:Autophagy plays an important role in maintaining intracellular homeostasis by promoting the transit of cytoplasmic material, such as proteins, organelles and pathogens, for degradation within acidic organelles. Yet, in immune cells, autophagy pathways serve an additional role in facilitating intracellular surveillance...

journal_title：Immunology

authors： Crotzer VL,Blum JS

更新日期：2010-09-01 00:00:00

abstract：:Selective Alzheimer disease indicator-1 (seladin-1) is a broadly expressed oxidoreductase and is related to Alzheimer disease, cholesterol metabolism and carcinogenesis. The effect of lipopolysaccharide (LPS) on the expression of seladin-1 was examined using RAW 264.7 macrophage-like cells and murine peritoneal macrop...

journal_title：Immunology

authors： Khuda II,Koide N,Noman AS,Dagvadorj J,Tumurkhuu G,Naiki Y,Komatsu T,Yoshida T,Yokochi T

更新日期：2010-09-01 00:00:00

abstract：:Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiation from the DN to DP...

journal_title：Immunology

authors： Wong WF,Nakazato M,Watanabe T,Kohu K,Ogata T,Yoshida N,Sotomaru Y,Ito M,Araki K,Telfer J,Fukumoto M,Suzuki D,Sato T,Hozumi K,Habu S,Satake M

更新日期：2010-06-01 00:00:00

abstract：:Neutrophils make up an essential part of the innate immune system, and are involved both in the initial responses to pathogens, and in orchestrating later immune responses. Neutrophils recognize pathogens through pattern-recognition receptors (PRRs), which are activated by microbial motifs. The Nod-like receptors (nuc...

journal_title：Immunology

authors： Ekman AK,Cardell LO

更新日期：2010-05-01 00:00:00

abstract：:The ultimate outcome of T-cell recognition of peptide-major histocompatibility complex (MHC) complexes is determined by the molecular context in which antigen presentation is provided. The paradigm is that, after exposure to peptides presented by steady-state dendritic cells (DCs), inhibitory signals dominate, leading...

journal_title：Immunology

authors： Konkel JE,Frommer F,Leech MD,Yagita H,Waisman A,Anderton SM

更新日期：2010-05-01 00:00:00

abstract：:While many aspects of memory T-cell immunobiology have been characterized, we suggest that we know only a fraction of the effector functions that CD4 T cells can bring to bear during secondary challenges. Exploring the full impact of memory CD4 T-cell responses is key to the development of improved vaccines against ma...

journal_title：Immunology

authors： McKinstry KK,Strutt TM,Swain SL

更新日期：2010-05-01 00:00:00

abstract：:Secretory proteins of Mycobacterium tuberculosis are the major immunomodulators of the host immune response. Open reading frame (ORF) Rv2626c, encoding a conserved hypothetical protein eliciting a strong humoral immune response in patients with tuberculosis (TB), was shown to be up-regulated upon infection in mice und...

journal_title：Immunology

authors： Bashir N,Kounsar F,Mukhopadhyay S,Hasnain SE

更新日期：2010-05-01 00:00:00

abstract：:Resveratrol is a polyphenol that acts on multiple molecular targets important for cell differentiation and activation. Dendritic cells (DCs) are a functionally diverse cell type and represent the most potent antigen-presenting cells of the immune system. In this study, we investigated resveratrol-induced effects on DC...

journal_title：Immunology

authors： Svajger U,Obermajer N,Jeras M

更新日期：2010-04-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I-specific inhibitory natural killer receptors (iNKRs) are expressed by subsets of T cells but the mechanisms inducing their expression are poorly understood, particularly for killer-cell immunoglobulin-like receptors (KIRs). The iNKRs are virtually absent from the surface ...

journal_title：Immunology

authors： Hermann E,Berthe A,Truyens C,Alonso-Vega C,Parrado R,Torrico F,Carlier Y,Braud VM

更新日期：2010-03-01 00:00:00

abstract：:We describe a high-throughput screening system to detect interactions between leucocyte surface proteins, taking into account that these interactions are usually of very low affinity. The method involves producing the extracellular regions of leucocyte proteins with tags so that they can be bound to nanoparticles to p...

journal_title：Immunology

authors： Jiang L,Barclay AN

更新日期：2010-01-01 00:00:00

abstract：:Endodontic infections are polymicrobial infections resulting in bone destruction and tooth loss. The host response to these infections is complex, including both innate and adaptive mechanisms. Osteopontin (OPN), a secreted, integrin-binding protein, functions in the regulation of immune responses and enhancement of l...

journal_title：Immunology

authors： Rittling SR,Zetterberg C,Yagiz K,Skinner S,Suzuki N,Fujimura A,Sasaki H

更新日期：2010-01-01 00:00:00

abstract：:Toll-like receptor-4 (TLR4) is important in protection against lethal Salmonella enterica serovar Typhimurium (S. Typhimurium) infection. Control of the early stages of sublethal S. Typhimurium infection in mice depends on TLR4-dependent activation of macrophages and natural killer (NK) cells to drive an inflammatory ...

journal_title：Immunology

authors： Talbot S,Tötemeyer S,Yamamoto M,Akira S,Hughes K,Gray D,Barr T,Mastroeni P,Maskell DJ,Bryant CE

更新日期：2009-12-01 00:00:00

abstract：:Deficiency in gammadelta T cells aggravates colitis in animal models suggesting that gammadelta T cells have regulatory properties. Therefore, proliferation, suppression and cytokine secretion of human gammadelta T cells were determined in vitro. Human peripheral gammadelta T cells were isolated from the whole blood o...

journal_title：Immunology

authors： Kühl AA,Pawlowski NN,Grollich K,Blessenohl M,Westermann J,Zeitz M,Loddenkemper C,Hoffmann JC

更新日期：2009-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key receptors of the innate immune system and show cell subset-specific expression. We investigated the messenger RNA (mRNA) expression of TLR genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells fr...

journal_title：Immunology

authors： Dorner M,Brandt S,Tinguely M,Zucol F,Bourquin JP,Zauner L,Berger C,Bernasconi M,Speck RF,Nadal D

更新日期：2009-12-01 00:00:00

abstract：:With an increase in the importance of umbilical cord blood (CB) as an alternative source of haematopoietic progenitors for allogenic transplantation, donor lymphocyte infusion (DLI) with donor CB-derived activated CD4(+) T cells in the unrelated CB transplantation setting is expected to be of increased usefulness as a...

journal_title：Immunology

authors： Miyagawa Y,Kiyokawa N,Ochiai N,Imadome K,Horiuchi Y,Onda K,Yajima M,Nakamura H,Katagiri YU,Okita H,Morio T,Shimizu N,Fujimoto J,Fujiwara S

更新日期：2009-11-01 00:00:00

abstract：:Anti-proteinase 3 antibodies are implicated in the pathogenesis of small vessel vasculitis. These are primarily immunoglobulin G (IgG), with different subclasses predominating at different stages of disease. However, little is known of their respective roles in pathogenesis. We have previously shown that patient IgG4 ...

journal_title：Immunology

authors： Hussain A,Pankhurst T,Goodall M,Colman R,Jefferis R,Savage CO,Williams JM

更新日期：2009-10-01 00:00:00

abstract：:NKG2D is one of the best characterized activating receptors and is expressed on natural killer cells and on various T-cell subsets. This receptor recognizes several different ligands that are induced by cellular stresses. In this review, we described the mechanisms controlling the expression of NKG2D ligands, with the...

journal_title：Immunology

authors： Stern-Ginossar N,Mandelboim O

更新日期：2009-09-01 00:00:00

abstract：:Macrophages have the potential to recognize apoptotic neutrophils and phagocytose them while the same function for monocytes is uncertain. In fact, early findings indicated that monocytes started to phagocytose neutrophils on the third day of differentiation to macrophages. Here we show, using flow cytometry and confo...

journal_title：Immunology

authors： Mikołajczyk TP,Skrzeczyńska-Moncznik JE,Zarebski MA,Marewicz EA,Wiśniewska AM,Dzieba M,Dobrucki JW,Pryjma JR

更新日期：2009-09-01 00:00:00

abstract：:Formation of osteoclasts and consequent joint destruction are hallmarks of rheumatoid arthritis (RA). Here we show that LIGHT, a member of the tumour necrosis factor (TNF) superfamily, induced the differentiation into tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells (MNCs) of CD14(+) monocytes ...

journal_title：Immunology

authors： Ishida S,Yamane S,Nakano S,Yanagimoto T,Hanamoto Y,Maeda-Tanimura M,Toyosaki-Maeda T,Ishizaki J,Matsuo Y,Fukui N,Itoh T,Ochi T,Suzuki R

更新日期：2009-09-01 00:00:00

abstract：:The opossum major histocompatibility complex (MHC) shares a similar organization with that of non-mammals while containing a diverse set of class I genes more like that of eutherian (placental) mammals. There are 11 class I loci in the opossum MHC region, seven of which are known to be transcribed. The previously desc...

journal_title：Immunology

authors： Baker ML,Melman SD,Huntley J,Miller RD

更新日期：2009-09-01 00:00:00

abstract：:Human haematopoietic progenitor/stem cells (HPCs) differentiate into functional T cells in the thymus through a series of checkpoints. A convenient in vitro system will greatly facilitate the understanding of T-cell development and future engineering of therapeutic T cells. In this report, we established a lentiviral ...

journal_title：Immunology

authors： Patel E,Wang B,Lien L,Wang Y,Yang LJ,Moreb JS,Chang LJ

更新日期：2009-09-01 00:00:00

abstract：:Within the lesions of inflammatory myopathies, muscle fibres and invading mononuclear cells express Fas and Fas ligand (FasL), respectively. However, the roles of the Fas/FasL interaction in the pathogenesis of inflammatory myopathies are not fully understood. In the present study, we investigated the roles of proinfl...

journal_title：Immunology

authors： Kondo M,Murakawa Y,Harashima N,Kobayashi S,Yamaguchi S,Harada M

更新日期：2009-09-01 00:00:00

abstract：:Apoptosis of macrophages infected with pathogenic mycobacteria is an alternative host defence capable of removing the environment supporting bacterial growth. In this work the influence of virulence and bacterial load on apoptosis of alveolar macrophages during the initial phase of infection by Mycobacterium bovis was...

journal_title：Immunology

authors： Rodrigues MF,Barsante MM,Alves CC,Souza MA,Ferreira AP,Amarante-Mendes GP,Teixeira HC

更新日期：2009-09-01 00:00:00

abstract：:Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is an important molecule in the down-regulation of T-cell activation. A study was undertaken to evaluate the association of the CTLA-4 gene polymorphisms -319C/T, +49A/G, (AT)(n), CT60A/G and Jo31G/T with the levels of membrane CTLA-4 (mCTLA-4) and cytoplasmic CTLA-4 (cCTLA-4)...

journal_title：Immunology

authors： Karabon L,Kosmaczewska A,Bilinska M,Pawlak E,Ciszak L,Jedynak A,Jonkisz A,Noga L,Pokryszko-Dragan A,Koszewicz M,Frydecka I

更新日期：2009-09-01 00:00:00

abstract：:The absence of complement receptor 1 (CR1) related gene/protein y (Crry) leads to embryonic lethality as a result of unrestricted complement activation and concomitant neutrophil infiltration. Here we used Crry(-/-)C3(+/-) mice to investigate the role of Crry in the pathogenesis of immune complex glomerulonephritis (G...

journal_title：Immunology

authors： Bao L,Wang Y,Chen P,Sarav M,Haas M,Minto AW,Petkova M,Quigg RJ

更新日期：2009-09-01 00:00:00

abstract：:The ultimate outcome of T cell receptor recognition is determined by the context in which the antigen is encountered. In this fashion both antigen-presenting cells and T cells must integrate multiple environmental cues in the form of pathogen-associated molecular patterns, cytokines and accessory molecule signals. The...

journal_title：Immunology

authors： Delgoffe GM,Powell JD

更新日期：2009-08-01 00:00:00

abstract：:We sought to determine whether Litomosoides sigmodontis, a filarial infection of rodents, protects against type 1 diabetes in non-obese diabetic (NOD) mice. Six-week-old NOD mice were sham-infected or infected with either L3 larvae, adult male worms, or adult female worms. Whereas 82% of uninfected NOD mice developed ...

journal_title：Immunology

authors： Hübner MP,Stocker JT,Mitre E

更新日期：2009-08-01 00:00:00

abstract：:Dendritic cells (DC) generated from MUTZ-3, an immortalized acute myeloid leukaemia-derived cell line, have potential application as a model for the study of human DC, and as a tool with which to stimulate immunotherapeutic responses to cancer. However, the relationship of MUTZ-3 DC to their non-transformed counterpar...

journal_title：Immunology

authors： Rasaiyaah J,Noursadeghi M,Kellam P,Chain B

更新日期：2009-07-01 00:00:00